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陈化兰

标签: 动物 传染病 研究员

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      陈化兰,女,1969年生,甘肃省白银市人,博士,研究员,博士生导师,动物传染病及预防兽医学专家。中国农业科学院兽医兽药学科“一级岗位杰出人才”。任世界动物卫生组织(OIE)生物标准委员会委员,OIE/国际粮农组织(FAO)禽流感专业委员会执行委员,OIE禽流感专家。中国农业科学院哈尔滨兽医研究所农业部动物流感重点开放实验室主任,国家禽流感参考实验室主任,OIE禽流感参考实验室主任。

目录

个人履历编辑本段回目录

学习经历

     1987-1991年,就读于甘肃农业大学兽医系,获学士学位;
     1991-1994年,就读于甘肃农业大学兽医系兽医病理专业,获硕士学位;
     1994-1997年,就读于中国农业科学院研究生院传染病与预防兽医学专业,获博士学位;
     1999-2002年,美国疾病控制中心(CDC)流感分中心进行禽流感合作研究,博士后。

工作经历

     1997-1999,中国农业科学院哈尔滨兽医研究所助理研究员;
     2002-今,中国农业科学院哈尔滨兽医研究所研究员,农业部动物流感重点开放实验室主任,国家禽流感参考实验室主任、研究员;
     2008-今,OIE禽流感参考实验室主任。

研究方向编辑本段回目录

陈化兰陈化兰

     为禽流感病毒跨种属感染及其致病性的分子遗传与分子致病机制。她是我国最早禽流感病毒(AIV)基因工程疫苗分子诊断及分子流行病学的研究者之一。她主持的农业部动物流感重点开放实验室是如今国内唯一有权对禽流感病毒进行最终病毒分离鉴定的研究机构,也是世界卫生组织全球动物流感监测网点实验室之一。该实验室分离鉴定了我国流行的禽流感病毒400多株,并建立了我国特有的禽流感病毒毒株及其信息资源库,所研制的禽流感诊断试剂和疫苗已在全国范围大面积推广、应用,创造了巨大的社会效益和经济效益。

学术成就编辑本段回目录

科研项目

      她主持国家禽流感参考实验室,系统开展了我国禽流感流行病学监测和研究工作,取得了一系列重大进展和创造性研究成果,初步阐明有关禽流感病毒的分子遗传、抗原变异及致病性演化规律,为疫情的预警预报、防制策略、诊断试剂及疫苗研制与使用提供了全面的科学依据。在防制禽流感期间,迅速准确确诊来自全国各地的大量样品,对疫情的及时有效控制起到了关键作用,她主持研制的有关禽流感灭活疫苗已累计推广应用60亿羽份以上,为防控禽流感疫情作出了重大贡献。
      主持国家禽流感参考实验室在动物流感尤其是禽流感的流行病学、诊断技术、新型疫苗研制、分子演变及分子致病机制等方面取得了一系列重大进展和创造性研究成果,研制成功了H5 亚型禽流感灭活疫苗和新型“禽流感、新城疫重组二联活疫苗”,代表了禽流感疫苗研制的国际先进水平和发展趋势,推广应用后,极大地提高了我国乃至世界防控禽流感的能力,具有十分重要的社会经济及公共卫生意义。

科研成就

     1994年以来,一直从事禽流感及猪流感相关基础研究和应用研究。国家杰出青年基金获得者,“973”项目首席科学家。先后主持国家“攻关”、“863”、“973”、国家自然科学基金等科研项目20多项;在国际重要学术杂志发表禽流感研究相关SCI论文50多篇;已获得6个禽流感疫苗新兽药证书,其中3个为基因工程疫苗;获得7项国家发明专利。主持完成成果“H5亚型禽流感灭活疫苗研制及其应用”获得2005年国家科技进步一等奖;主持完成成果“重组禽流感、新城疫二联活疫苗”获得2007年国家技术发明二等奖。主持研发的各种禽流感疫苗在国内外推广应用700多亿羽份。
      2013年4月,陈化兰和她的科研团队发现,在中国导致人感染的新型H7N9流感病毒,与同一时期存在于活禽市场上的H7N9禽流感病毒高度同源,在国际上首次从病原学角度揭示了新型H7N9流感病毒的来源,为中国科学防控H7N9禽流感提供了重要依据。5月,她们又发现H5N1病毒确有可能通过与人流感病毒的基因重配,获得在哺乳动物之间高效空气传播的能力,从而具备引起人间大流行的潜力,从全新的角度揭示了H5N1病毒对全球公共卫生构成的现实威胁。7月,她和科研人员研究发现,H7N9病毒对禽类无致病力,但该病毒侵入人体发生突变后,对哺乳动物的致病力与水平传播能力得到明显增强,从而揭示了H7N9病毒存在较大人间大流行的风险。这些成果先后发表在《科学通报》英文版及《科学(SCIENCE)》杂志上[1]  。
      2015年,由来自国际科学界的13名著名科学家组成的独立国际评委会,从超过2600名杰出女科学家提名人选中遴选出5位2016年联合国教科文组织-欧莱雅“世界杰出女科学家成就奖”获得者。陈化兰因“在禽流感生物学领域的杰出研究,流感有效疫苗开发及应用方面的领先成果”而获选。
      “世界杰出女科学家成就奖”由联合国教科文组织和法国欧莱雅集团于1998年共同创立,旨在表彰女科学家的杰出成就,对她们所做出的卓越贡献给予充分的认可,并为其科研事业提供支持。该奖项每年在5个代表区域(欧洲、北美洲、非洲及阿拉伯国家、亚洲及太平洋地区、拉丁美洲)各选出1名女科学家进行奖励。至今,中国(包括中国香港在内)共有5位女科学院家获得该奖项。
      获得2016年该奖项的5位科学家将于2016年3月24日在巴黎的索邦大学接受每人10万欧元的奖励,以表彰她们在科学领域的贡献。

论文著作

      1. Yanbing Li, Liling Liu, Yi Zhang, Zhenhua Duan, Guobin Tian, Xianying Zeng, Jianzhong Shi, Licheng Zhang, Hualan Chen*. New lineage of H5N1 influenza virus detected in wild birds in Qinghai, western China. Emerging Infectious Disease, 2010, in press.
      2. Ying Chen, Gongxun Zhong, Guojun Wang, Guohua Deng, Yanbing Li, Jianzhong Shi, Zhuo Zhang, Yuntao Guan, Yongping Jiang, Zhigao Bu, Yoshihiro Kawaoka, Hualan Chen*. Dogs are highly susceptible to H5N1 avian influenza virus. Virology. 2010, 405, 15-19, on-line, June 25.
      3. Lihong Tao, Jinying Ge, Xijun Wang, Hongyue Zhai, Tao Hua, Bolin Zhao, Dongni Kong, Chinglai Yang, Hualan Chen*, and Zhigao Bu*. Molecular Basis of Neurovirulence of Flury Rabies Virus Vaccine Strains: Importance of the Polymerase and the Glycoprotein R333Q Mutation. Journal of Virology. 2010, 84 (17), 8926-8936. on-line, June 10
      4. Yanbing Li, Jianzhong Shi, Gongxun Zhong, Guohua Deng, Guobin Tian, Jinying Ge, Xianying Zeng, Jiasheng Song, Dongming Zhao, Liling Liu, Yongping Jiang, Yuntao Guan, Zhigao Bu, Hualan Chen*. Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry and humans in China from 2004 to 2009. Journal of Virology. 2010, 84(17), 8389-8379. On-line, June 10.
      5. Yujie Tang, Gongxun Zhong, Lianhui Zhu, Xing Liu, Yufei Shan, Huapeng Feng, Zhigao Bu, Hualan Chen*, and Chen Wang. Herc5 Attenuates Influenza A Virus by Catalyzing ISGylation of Viral NS1 Protein. Journal of Immunology, 2010, 184, 5777-5790
      6. Bo Wah Leung, Hualan Chen, George G. Brownlee. Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity. Virology, 2010, 401:96-106.
      7. Yuwei Gao, Ying Zhang, Kyoko Shinya, Guohua Deng, Yongping Jiang, Zejun Li, Yutao Guan, Guobin Tian, Yanbing Li, Jianzhong Shi, Liling Liu, Xianying Zeng, Zhigao Bu, Xianzhu Xia, Yoshihiro Kawaoka, Hualan Chen*. Identification of Amino Acids in HA and PB2 Critical for the Transmission of H5N1 Avian Influenza Viruses in a Mammalian Host. PLoS Pathogens, 2009, 5(12): e1000709.
     8. Yongping Jiang, Hongbo Zhang, Guojun Wang, Pingjing Zhang, Guobin Tian, Zhigao Bu, and Hualan Chen*. Protective Efficacy of H7 Subtype Avian Influenza DNA Vaccine. Avian Disease, 2010, 54(S1), 294-296.
     9. Jinying Ge, Guobin Tian, Xianying Zeng, Yongping Jiang, Hualan Chen and Zhigao Bu*. Generation and Evaluation of a Newcastle Disease Virus-Based H9 Avian Influenza Live Vaccine. Avian Disease, 2010, 54(S1), 290-293.
     10. Guobin Tian, Xianying Zeng, Yanbing Li, Jianzhong Shi, Hualan Chen*. Protective Efficacy of the H5 Inactivated Vaccine against Different Highly Pathogenic H5N1 Avian Influenza Viruses Isolated in China and Vietnam. Avian Disease, 2010, 54(S1), 287-289.
     11. Neumann G, Chen H, Gao GF, Shu Y, Kawaoka Y. H5N1 influenza viruses: outbreaks and biological properties. Cell Research, 2010, 20(1):51-61
     12. Qimeng Tao , Xiurong Wang, Hongmei Bao, Jianan Wu , Lin Shi, Yanbing Li, Chuanling Qiao , Yakovlevich SA, Mikhaylovna PN, Hualan Chen. Detection and differentiation of four poultry diseases using asymmetric reverse transcription polymerase chain reaction in combination with oligonucleotide microarrays. J Vet Diagn Invest. 2009;21(5):623-632
     13. Chuantian Xu, Qiyun Zhu, Huanliang Yang, Xiumei Zhang, Chuanling Qiao, Yan Chen, Xiaoguang Xin, Hualan Chen*. Two genotypes of H1N2 influenza viruses appeared among pigs in China. Journal of Clinical Virology. 2009, 46: 192-195.
     14. Hualan Chen, Zhigao Bu. Development and application of avian influenza vaccines in China. Current Topics in Microbiology and Immunology. 2009;333:153-62 (Review)
     15. Hualan Chen. Avian influenza vaccination: the experience in China. Rev Sci Tech. 2009, 28(1): 267-74 (Review)
     16. Jiyong Zhou, Wenbo Sun, Junhua Wang, Junqing Guo, Wei Yin, Nanping Wu, Lanjuan Li, Yan Yan, Ming Liao, Yu Huang, Kaijian Luo, Xuetao Jiang, Hualan Chen. Characterization of the H5N1 Highly Pathogenic Avian Influenza Virus derived from Wild Pikas in China. J Virol. 2009, 83: 8957-8964
     17. Hualan Chen. H5N1 avian influenza in China. Sci China C Life Sci. 2009, 52(5):419-27. (Review)
     18. Szretter KJ, Gangappa S, Belser JA, Zeng H, Chen H, Matsuoka Y, Sambhara S, Swayne DE, Tumpey TM, Katz JM. Early Control of H5N1 Influenza Virus Replication by the Type I Interferon Response in Mice. J Virol. 2009 83(11): 5825-34
     19. Kashiwagi T, Leung BW, Deng T, Chen H, Brownlee GG.. The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) influences promoter binding. PLoS ONE. 2009; 4(5):e5473.
     20. Shufang Fan, Yuwei Gao, Kyoko Shinya, Chris K-F. Li, Yanbing Li, Jianzhong Shi, Yongping Jiang, Yongbing Suo, Tiegang Tong, Gongxun Zhong, Jiasheng Song, Ying Zhang, Guobin Tian, Yuntao Guan, Xiaoning Xu, Zhigao Bu, Yoshihiro Kawaoka , Hualan Chen. Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates. PLoS Pathogens, 2009, 5(5), e1000409
     21. Chuanling Qiao, Yongping Jiang, Guobin Tian, Xiurong Wang, Chengjun Li, Xiaoguang Xin, Hualan Chen, Kangzhen Yu. Recombinant Fowlpox Virus Vector-based Vaccine Completely Protects Chickens from H5N1 Avian Influenza Virus. Antiviral Research, 2009, 81(3):234-8
     22. Shufang Fan, Guohua Deng, Jiasheng Song, Guobin Tian, Yongbing Suo, Yongping Jiang, Yuntao Guan, Zhigao Bu, Yoshihiro Kawaoka, Hualan Chen. Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice. Virology, 2009, 384: 29-32
     23. Murakami S, Horimoto T, Mai le Q, Nidom CA, Chen H, Muramoto Y, Yamada S, Iwasa A, Iwatsuki-Horimoto K, Shimojima M, Iwata A, Kawaoka Y. Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells. Journal of Virology, 2008, 82: 10502-9
     24. Beibei Jia, Jianzhong Shi, Yanbing Li, Kyoko Shinya, Yukiko Muramoto, Xianying Zeng, Guobin Tian, Yoshihiro Kawaoka, Hualan Chen. Pathogenicity of Chinese H5N1 Highly Pathogenic Avian Influenza Viruses in Pigeons. Archives of Virology, 2008, 153: 1821-1826
     25. Chengjun Li, Jihui Ping, Bo Jing, Guohua Deng, Yongping Jiang, Yanbing Li, Guobin Tian, Kangzhen Yu, Zhigao Bu, Hualan Chen. H5N1 influenza marker vaccine for serological differentiation between vaccinated and infected chickens. Biochemical and Biophysical Research Communications, 2008, 372(2): 293-7
     26. Kiyoko Iwatsuki-Horimoto, Yasuko Hatta, Masato Hatta, Yukiko Muramoto, Hualan Chen, Yoshihiro Kawaoka, Taisuke Horimoto. Limited compatibility between the RNA polymerase components of influenza virus type A and B. Virus Research, 2008, 135(1): 161-5
     27. Jihui Ping, Chengjun Li, Guohua Deng, Yongping Jiang, Guobin Tian, Shuxia Zhang, Zhigao Bu and Hualan Chen. Single-amino-acid mutation in the HA alters the recognition of H9N2 influenza virus by a monoclonal antibody. Biochemical and Biophysical Research Communications, 2008, 371(1): 168-371
     28. Peirong Jiao, Guobin Tian, Yanbing Li, Guohua Deng, Yongping Jiang, Chang Liu, Weilong Liu, Zhigao Bu, Yoshihiro Kawaoka, Hualan Chen. A single amino acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice. Journal of Virology, 2008, 82 (3): 1146–1154.
Comment in Journal of Virology: Single-Amino-Acid Substitution Changes the Virulence of H5N1 Influenza Viruses. Journal of Virology, 2008, 82 (3): 1065
Comment in Microbe: Single-Amino-Acid Substitution Changes the Virulence of H5N1 Influenza Viruses.
     29. Qiyun Zhu, Huangliang Yang, Weiye Chen, Wenyan Cao, Gongxun Zhong, Peirong Jiao, Guohua Deng, Kangzhen Yu, Chinglai Yang, Zhigao Bu, Yoshihiro Kawaoka, Hualan Chen. A naturally occurring deletion in its NS gene contributes to attenuation of an H5N1 swine influenza virus in chickens. Journal of Virology, 2008, 82 (1):220–228.
     30. Hualan Chen, Rick Bright, Kanta Subbarao, Catherine Smith, Nancy Cox, Jacqueline M. Katz, and Yumiko Matsuoka. Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice. Virus Research, 2007, 128(1-2):159-63.
     31. Yongping Jiang, Kangzhen Yu, Hongbo Zhang, Pingjing Zhang, Chenjun Li, Guobin Tian, Yanbing Li, Xijun Wang, Zhigao Bu, Hualan Chen. Enhanced protective efficacy of H5 subtype avian influenza DNA vaccine with codon optimized HA gene in a pCAGG plasmid vector. Antiviral Research, 2007, 75: 234-241.
     32. Jinying Ge, Guohua Deng, Zhiyuan Wen, Guobing Tian, Yong Wang, Jianzhong Shi, Xijun Wang, Yanbing Li, Sen Hu, Yongping Jiang, Chinglai Yang, Kangzhen Yu, Zhigao Bu, Hualan Chen. Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses. Journal of Virology, 2007, 81, 150-158.
     33. Chuanling Qiao, Guobin Tian, Yongping Jiang, Yanbing Li, Jianzhong Shi, Kangzhen Yu, Hualan Chen. Vaccines Developed for H5 Highly Pathogenic Avian Influenza in China. Ann. N.Y. Acad. Sci. 2006, 1081: 182–192
     34. Zejun Li, Yongping Jiang, Peirong Jiao, Aiqin Wang, Fengju Zhao, Guobin Tian, Xijun Wang, Kangzhen Yu, Zhigao Bu and Hualan Chen. The NS1 Gene Contributes to the Virulence of H5N1 Avian Influenza Viruses. Journal of Virology, 2006, 80:11115-11123.
     35. Taronna R. Maines, Li-Mei Chen, Yumiko Matsuoka, Hualan Chen, Thomas Rowe, Juan Ortin, Ana Falco’n, Nguyen Tran Hien, Le Quynh Mai, Endang R. Sedyaningsih, Syahrial Harun, Terrence M. Tumpey, Ruben O. Donis, Nancy J. Cox, Kanta Subbarao, and Jacqueline M. Katz. Lack of transmission of H5N1 avian–human reassortant influenza viruses in a ferret model. Proc. Natl. Acad. Sci. USA, 2006, 103(32): 12121-12126
     36. Hualan Chen, Yanbing Li, Zejun Li, Jianzhong Shi, Kyoko Shinya, Guohua Deng, Qiaoling Qi, Guobin Tian, Shufang Fan, Haidan Zhao, Yingxiang Sun, Yoshihiro Kawaoka. Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. Journal of Virology, 2006, 80(12):5976-83.
     37. Yanbing Li, Chengjun Li, Liling Liu, Hongwei Wang, Chuanbin Wang, Guobing Tian, Robert. G. Webster, Kangzhen Yu, Hualan Chen. Characterization of an avian influenza virus of subtype H7N2 isolated from chickens in northern China. Virus Genes, 2006, 33:117-122
     38. Yanbing Li, Zhixiong Lin, Jianzhong Shi, Qiaoling Qi, Guohua Deng, Zejun Li, Xiurong Wang, Guobin Tian, Hualan Chen. Detection of Hong Kong 97-like H5N1 influenza viruses from eggs of Vietnamese waterfowl. Archives of Virology. 2006, 151: 1615-1624
     39. Yu H, Shu Y, Hu S, Zhang H, Gao Z, Chen H, Dong J, Xu C, Zhang Y, Xiang N, Wang M, Guo Y, Cox N, Lim W, Li D, Wang Y, Yang W. The first confirmed human case of avian influenza A (H5N1) in Mainland China. Lancet. 2006, 7: 367(9504):84.
     40. Zejun Li, Hualan Chen, Peirong Jiao, Guohua Deng, Guobin Tian, Yanbing Li, Erich Hoffmann, Robert G. Webster, Yumiko Matsuoka, Kangzhen Yu. Molecular basis associated with replication of duck H5N1 influenza viruses in a mammalian mouse model. Journal of Virology, 2005, 79: 12058–12064
     41. Guobin Tian, Suhua Zhang, Yanbing Li, Zhigao Bu, Peihong Liu, Jinping Zhou, Chengjun Li, Jianzhong Shi, Kangzhen Yu, Hualan Chen. Protective efficacy in chickens, geese and ducks of an H5N1 inactivated vaccine developed by reverse genetics. Virology, 2005, 341: 153 – 162
     42. Chengjun Li, Kangzhen Yu, Guobin Tian, Dandan Yu, Liling Liu, Bo Jing, Jihui Ping, and Hualan Chen. Evolution of H9N2 influenza viruses from domestic poultry in Mainland China. Virology, 2005, 340: 70 – 83
     43. K. M. Sturm-Ramirez, D. J. Hulse-Post, E. A. Govorkova, J. Humberd, P. Seiler, P. Puthavathana, C. Buranathai, T. D. Nguyen, A. Chaisingh, H. T. Long, T. S. P. Naipospos, H. Chen, T. M. Ellis, Y. Guan, J. S. M. Peiris, and R. G. Webster. Are Ducks Contributing to the Endemicity of Highly Pathogenic H5N1 Influenza Virus in Asia. Journal of Virology, 2005, 79(17): 11269-11279
     44. D. J. Hulse-Post, K. M. Sturm-Ramirez, J. Humberd, P. Seiler, E. A. Govorkova, S. Krauss, C. Scholtissek, P. Puthavathana, C. Buranathai, T. D. Nguyen, H. T. Long, T. S. P. Naipospos, H. Chen, T. M. Ellis, Y. Guan, J. S. M. Peiris and R. G. Webster. Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia. Proc. Natl. Acad. Sci. USA, 2005, 102: 10682-10687
     45. H. Chen,G. Deng,Z. Li,G. Tian,Y. Li,P. Jiao, L. Zhang, Z. Liu, R. G. Webster, K. Yu. The evolution of H5N1 influenza viruses in ducks in Southern China. Proc. Natl. Acad. Sci. USA, 2004, 101(28): 10452-10457
  Comments in Nature: Increasing virulence of bird flu threatens mammals. Nature, 2004, 431, July 1, 4.
     46. Hualan Chen, Yumiko Matsuoka, David Swayne, Qi Chen, Nancy Cox, Brain R. Murphy and Kanta Subbarao. Generation and Characterization of an H9N2 Cold-Adapted Reassortant as a Vaccine Candidate, Avian Diseases 2003, 47, 1127-1130
     47. Yumiko Matsuoka, Hualan Chen, David Swayne, Safety Evaluation in Chickens of Candidate Human Vaccines against Potential Pandemic Strains of Influenza Avian Diseases, 2003, 47, 926-930
     48. Hualan Chen, Yumiko Matsuoka, David Swayne, Qi Chen, Nancy Cox, Brain R. Murphy and Kanta Subbarao. Generation and characterization of a cold-adapted influenza A H9N2 reassortant as a live pandemic influenza vaccine candidate. Vaccine, 2003, 21(27-28): 4430-4436
     49. Hualan Chen, Kanta Subbarao, David Swayne, Qi Chen, Xiuhua Lu, Jacqueline Katz, Nancy Cox and Yumiko Matsuoka, Generation and evaluation of a high-growth reassortant H9N2 influenza A virus as a pandemic vaccine candidate. Vaccine 2003, 21(17): 1974-1979
     50. Kanta Subbarao, Hualan Chen, David Swayne, Louise Mingay, Ervin Fodor, George Brownlee, Xiyan Xu, Xiuhua Lu, Jacqueline Katz, Nancy Cox and Yumiko Matsuoka. Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics. Virology, 2003, 1.Jan 5, 305(1): 192-200
Book Chapters:
     51. Hualan Chen, Zhigao Bu, Jingfei Wang. Epidemiology and Control of H5N1 Avian Influenza in China. Klenk H-D, Matrosovich MN, Stech J (eds): Avian Influenza. Monogr Virol. Basel, Karger, 2008, vol 27, 27-40

获奖记录

    2005年获国家科技进步一等奖,成果名称“禽流感灭活疫苗的研制和应用”
    2007年获国家技术发明二等奖,成果名称“重组禽流感、新城疫二联活疫苗”
    2009年获黑龙江省自然科学一等奖,成果名称“H5N1亚型禽流感病毒进化、跨宿主感染及致病力分子机制研究”
    2010年获黑龙江省科学进步一等奖,成果名称“禽流感(H5+H9)二价灭活疫苗”
    2005年获“中国青年女科学家奖”
    2005年获首届“中华农业英才奖”
    2006年获“何梁何利基金科学与技术创新奖(青年创新奖)”
    2006年获“全国五一劳动奖章”
    2006年获“中国青年五四奖章”
    2007年获“中国青年科技奖”
    2008年获“国家杰出青年基金”
    先后获得国家科技进步一等奖、国家技术发明二等奖。
    黑龙江省五一劳动奖章等荣誉称号。
    2009 年被授予新中国成立60 周年“三农”模范人物荣誉称号。
    英国《自然》杂志网站18日公布了该刊评出的2013年度全球科学界十大人物,中国禽流感专家陈化兰等人因在各自领域作出突出贡献而当选。
    2013年12月19日出版的《自然(Nature)》杂志评选出2013年年度十大科学人物,陈化兰研究员因禽流感病毒研究方面的卓越成绩而榜上有名 。
    2015年10月2日联合国教科文组织公布了2016年生命科学领域的5位“世界杰出女科学家成就奖”获得者名单,陈化兰研究员作为亚洲及太平洋地区的杰出代表获此殊荣。
    2016年6月2日,陈化兰荣获首届“全国杰出科技人才”奖。

参考资料
[1].  陈化兰   https://baike.baidu.com/item/%E9%99%88%E5%8C%96%E5%85%B0/8594368?fr=aladdin

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